Vitamins and Hormones : hormones and transport systems

Free download. Book file PDF easily for everyone and every device. You can download and read online Vitamins and Hormones : hormones and transport systems file PDF Book only if you are registered here. And also you can download or read online all Book PDF file that related with Vitamins and Hormones : hormones and transport systems book. Happy reading Vitamins and Hormones : hormones and transport systems Bookeveryone. Download file Free Book PDF Vitamins and Hormones : hormones and transport systems at Complete PDF Library. This Book have some digital formats such us :paperbook, ebook, kindle, epub, fb2 and another formats. Here is The CompletePDF Book Library. It's free to register here to get Book file PDF Vitamins and Hormones : hormones and transport systems Pocket Guide.


  1. Your Body's Systems
  2. Navigation menu
  3. Steroid hormone - Wikipedia
  4. Navigation menu

In adult rats, however, this effect disappears and adult erythropoiesis takes place.

  • In My Fathers Garden: A Daughters Search for a Spiritual Life.
  • Conflict in the Archaeology of Living Traditions.
  • Integrated Silicon Optoelectronics.
  • The Funny Thing Is....
  • Chapter 6. The Vitamins.

It is now known that vitamin A and RA and metabolites are involved in some glands development as well as functions in adults. Indeed, one of the most critical roles of vitamin A in human health is its effect on thyroid function as simultaneous iodine and vitamin A deficiencies potentiate to affect thyroid function. To achieve adequate intake of these micronutrients, among others, is indeed a challenge in developing countries. Similarly, the role of vitamin A and metabolites is certainly important in the regulation of the HPA axis although the endocrine consequences on the whole population is more difficult to assess.

  1. Research Methodologies in Supply Chain Management.
  2. Should Have Killed The Kid.
  3. Endocrinología y Nutrición (English Edition).
  4. Thanks to a better understanding of vitamin A and RA metabolites mechanisms of action through their various receptors some interesting pathways in normal or tumoural endocrine tissues have been uncovered. However, useful therapeutic use of agonists or antagonists of these pathways is not available yet. A use of retinoids in pituitary tumours especially corticotroph adenomas may be emerging.

    Well-tolerated, clinically available retinoids used for skin or hematologic diseases, renders clinical studies comparing other medical options readily possible.

    Your Body's Systems

    The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of this review. This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector. National Center for Biotechnology Information , U.

    Journal List Endocr Connect v. Endocr Connect. Published online Jul Author information Article notes Copyright and License information Disclaimer. Corresponding author. Correspondence should be addressed to J B Corcuff; Email: rf. Received Jul 3; Accepted Jul This article has been cited by other articles in PMC. Abstract Vitamin A retinol is a micronutrient critical for cell proliferation and differentiation. Keywords: vitamin A, retinol, hormones. Introduction Vitamin A retinol is a lipophilic micronutrient that is critical for embryo and child development 1 , 2.

    Brief physiology of the retinoids Natural retinoids absorption Retinoids constitute the family of molecules that includes both naturally occurring compounds with vitamin A activity as well as synthetic analogues of retinol or retinoic acid. Retinoids cellular effects In tissues, retinol cellular uptake can depend on passive diffusion.

    Open in a separate window. Figure 1. Vitamin A and the hypothalamo—pituitary—peripheral gland axes There are arguments for a role of retinoids in the development and function of the hypothalamus, the pituitary and the peripheral glands they act upon. Vitamin A and the hypothalamo—pituitary—thyroid axis RA does not seem to be involved in thyroid organogenesis Vitamin A and thyroid C cells No information has been reported about a role of RA and calcitonin secretion by normal thyroid C cells.

    Vitamin A and the hypothalamo—pituitary—gonads axis RA is a critical factor for the formation of the gonads in man and one of the major consequences of vitamin A deficiency apart from blindness is infertility 35 , Vitamin A and the somato-lactotroph axis RA probably plays a role not only in the differentiation of somatotrophs through pit-1 transcription factor 79 but also in the expression of growth hormone-releasing hormone GH-RH receptors in somatotrophs as there is a RARE in the promoter of GH-RH receptor gene Vitamin A and the pancreas RA receptor signalling is required in early pancreatic progenitor cells for pancreatic development Miscellaneous There are in vivo and in vitro arguments in animals reporting the effects of RA on renin or angiotensin production 96 , 97 , 98 , Conclusion It is now known that vitamin A and RA and metabolites are involved in some glands development as well as functions in adults.

    Declaration of interest The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of this review. Funding This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector. References 1. Vitamin A: a multifunctional tool for development.

    Seminars in Cell and Developmental Biology Retinoids, retinoic acid receptors, and cancer. Annual Review of Pathology A vitamin for the brain. Trends in Neurosciences Vitamin A metabolism: an update. Nutrients Harrison EH. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids.

    Main navigation

    Biochimica et Biophysica Acta Retinol and retinyl esters: biochemistry and physiology. Journal of Lipid Research Reboul E. Absorption of vitamin A and carotenoids by the enterocyte: focus on transport proteins. Retinyl ester hydrolases and their roles in vitamin A homeostasis.

    Allen LH, Haskell M. Estimating the potential for vitamin A toxicity in women and young children. Journal of Nutrition Molecular basis for Vitamin A uptake and storage in vertebrates. The multifaceted nature of retinoid transport and metabolism. Hepatobiliary Surgery and Nutrition ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta, beta-carotene absorption and vitamin A production. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science Slavotinek AM. Eye development genes and known syndromes.

    Molecular Genetics and Metabolism Thatcher JE, Isoherranen N. The role of CYP26 enzymes in retinoic acid clearance. Expert Opinion Drug Metabolism Toxicology A clinical and experimental overview of sirenomelia: insight into the mechanisms of congenital limb malformations. Disease Models and Mechanisms Identification of 9-cis-retinoic acid as a pancreas-specific autacoid that attenuates glucose-stimulated insulin secretion. PNAS Biochemical Pharmacology Retinol dehydrogenases RDHs in the visual cycle.

    Experimental Eye Research Rochette-Egly C, Germain P. Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors RARs. Nuclear Receptor Signaling An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature Calmodulin kinase II activation of mitogen-activated protein kinase in PC12 cell following all-trans retinoic acid treatment.

    Neurotoxicology Retinoic acid increases glucocorticoid receptor phosphorylation via cyclin-dependent kinase 5. Molecular and Cellular Neuroscience The involvement of retinoic acid receptor-alpha in corticotropin-releasing hormone gene expression and affective disorders. Biological Psychiatry Distribution of retinoic acid receptor-alpha immunoreactivity in the human hypothalamus. Neuroscience Retinoic acids and thyroid hormone act synergistically with dexamethasone to increase growth hormone-releasing hormone receptor messenger ribonucleic acid expression.

    Endocrinology A composite hormone response element regulates transcription of the rat GHRH receptor gene. Estrogen receptor alpha regulates retinaldehyde dehydrogenase 1 expression in rat anterior pituitary cells. Endocrine Journal Retinoic acid modulation of thyroid dual oxidase activity in rats and its impact on thyroid iodine organification. Journal of Endocrinology Expression of retinaldehyde dehydrogenase 1 in the anterior pituitary glands of adult rats.

    Navigation menu

    Cell and Tissue Research Zimmermann MB. Interactions of vitamin A and iodine deficiencies: effects on the pituitary-thyroid axis. International Journal for Vitamin and Nutrition Research Vitamin A supplementation in iodine-deficient African children decreases thyrotropin stimulation of the thyroid and reduces the goiter rate.

    American Journal of Clinical Nutrition Hess SY. The impact of common micronutrient deficiencies on iodine and thyroid metabolism: the evidence from human studies. Best Practice and Research Haider SG. Cell biology of Leydig cells in the testis. International Review of Cytology Clagett-Dame M, Knutson D.

    Endocrinology - Calcium and Phosphate Regulation

    Vitamin A in reproduction and development. Effects of chronic retinoid administration on pituitary function. Journal of Endocrinological Investigation Minireview: intrinsic and extrinsic factors in thyroid gland development: an update. The effects of vitamin A deficiency and vitamin A supplementation on thyroid function in goitrous children.

    Steroid hormone - Wikipedia

    Journal of Clinical Endocrinology and Metabolism Effect of vitamin A on the hypothalamo-pituitary-thyroid axis. American Journal of Physiology The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake. Cancer Biotherapy and Radiopharmaceuticals Retinoic acid inhibits human thyroid peroxidase and thyroglobulin gene expression in cultured human thyrocytes. Expression of all-trans-retinoic acid receptor RNA in human thyroid cells.

    Biochemistry and Molecular Biology International Biochemical and Biophysical Research Communications Endocrine-Related Cancer Redifferentiation therapy with retinoic acid in follicular thyroid cancer. Journal of Nuclear Medicine Redifferentiation therapy with retinoids: therapeutic option for advanced follicular and papillary thyroid carcinoma. World Journal of Surgery Tumour re-differentiation effect of retinoic acid: a novel therapeutic approach for advanced thyroid cancer. Current Pharmaceutical Design Schmutzler C, Koehrle J. Innovative strategies for the treatment of thyroid cancer.

    European Journal of Endocrinology Standard and emerging therapies for metastatic differentiated thyroid cancer. Oncologist Kogai T, Brent GA.

    Navigation menu

    The sodium iodide symporter NIS : regulation and approaches to targeting for cancer therapeutics. Pharmacology and Therapeutics Retinoic acid induces expression of the thyroid hormone transporter, monocarboxylate transporter 8 Mct8. Journal of Biological Chemistry Bernal J. Thyroid hormone transport in developing brain.

    Current Opinion in Endocrinology, Diabetes and Obesity A novel cytoplasmic adaptor for retinoic acid receptor RAR and thyroid receptor functions as a Derepressor of RAR in the absence of retinoic acid.